Brief Communications Tuning the Period of the Mammalian Circadian Clock: Additive and Independent Effects of CK1 Tau and Fbxl3 Mutations on Mouse Circadian Behavior and Molecular Pacemaking
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چکیده
Elizabeth S. Maywood,1 Johanna E. Chesham,1 Qing-Jun Meng,2 Patrick M. Nolan,3 Andrew S. I. Loudon,2 and Michael H. Hastings1 1Division of Neurobiology, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom, 2Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom, and 3Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX11 0RD, United Kingdom
منابع مشابه
Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins
The intrinsic period of circadian clocks is their defining adaptive property. To identify the biochemical mechanisms whereby casein kinase1 (CK1) determines circadian period in mammals, we created mouse null and tau mutants of Ck1 epsilon. Circadian period lengthened in CK1epsilon-/-, whereas CK1epsilon(tau/tau) shortened circadian period of behavior in vivo and suprachiasmatic nucleus firing r...
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تاریخ انتشار 2011